Article

Spatial transcriptomics uncovers hybrid, pro-inflammatory and pro-fibrotic cellular niches in pulmonary granuloma of patients with chronic sarcoidosis

2025-02-12

Abstract excerpt

<h4>Background</h4> Sarcoidosis is a disease of unknown etiology characterized by the formation of immune cell accumulation (granuloma) in the lung and other tissues. Chronic sarcoidosis may lead to pulmonary fibrosis. <h4>Aim</h4> To unravel cellular niches within pulmonary granuloma of chronic sarcoidosis patients using spatial transcriptomics. <h4>Methods</h4> Spatial transcriptomics using the Visium platfor...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 8cb96385-55fc-52cc-8b96-792235a2d830
DOI: 10.1101/2025.02.11.636632

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Spatial transcriptomics uncovers hybrid, pro-inflammatory and pro-fibrotic cellular niches in pulmonary granuloma of patients with chronic sarcoidosisDOI 10.1101/2025.02.11.636632Read

Transcriptional and Immune Landscape of Cardiac SarcoidosisSemantic proximity Read

Differential transcriptomics in sarcoidosis lung and lymph node granulomas with comparisons to pathogen-specific granulomasSemantic proximity Read

A multicenter spatial transcriptomics atlas of human tuberculosis and non-tuberculous mycobacterial diseaseSemantic proximity Read

Single Cell Transcriptome Signatures of Sarcoidosis in Lung Immune Cell PopulationsSemantic proximity Read

Severe Sarcoidosis Demonstrates Heterogenous Immune Dysregulation Across Different Peripheral Immune Cell Types: A Single-Center Single Cell Multi-omic AnalysisSemantic proximity Read

Transcriptome profiles in sarcoidosis and their potential role in disease predictionSemantic proximity Read

Bioinformatics analysis of potential biomarkers associated with diagnosis and treatment of sarcoidosis involved with different tissuesSemantic proximity Read

Phenotypes and Endotypes in Sarcoidosis: Unraveling Prognosis and Disease CourseSemantic proximity Read

Transcriptomics of Bronchoalveolar Lavage Cells Identifies New Molecular Endotypes of SarcoidosisSemantic proximity Read

Transcriptomics of bronchoalveolar lavage cells identifies new molecular endotypes of sarcoidosisSemantic proximity Read

Single-Cell and Spatial Transcriptomic Analyses Deciphering the Three-Layer Architecture of Human Tuberculosis GranulomasSemantic proximity Read