Article

Clearance of defective muscle stem cells by senolytics reduces the expression of senescence-associated secretory phenotype and restores myogenesis in myotonic dystrophy type 1

2022-06-25

Abstract excerpt

<h4>ABSTRACT</h4> Muscle weakness and atrophy are clinical hallmarks of myotonic dystrophy type 1 (DM1). Muscle stem cells, which contribute to skeletal muscle growth and repair, are also affected in this disease. However, the molecular mechanisms leading to this defective activity and the impact on the disease severity are still elusive. Here, we explored through an unbiased approach the molecular signature lead...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 75cde307-9b0e-5f8d-aabd-047979c8588c
DOI: 10.1101/2022.06.22.497227

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Clearance of defective muscle stem cells by senolytics reduces the expression of senescence-associated secretory phenotype and restores myogenesis in myotonic dystrophy type 1DOI 10.1101/2022.06.22.497227Read

Clearance of defective muscle stem cells by senolytics restores myogenesis in myotonic dystrophy type 1Semantic proximity Read

Senolytic elimination of senescent macrophages restores muscle stem cell function in severely dystrophic muscleSemantic proximity Read

Murine Myoblasts Exposed to SYUIQ-5 Acquire Senescence Phenotype and Differentiate into Sarcopenic-Like Myotubes, an In Vitro Study.Semantic proximity Read

Senolytic-Resistant Senescent Cells Have a Distinct SASP Profile and Functional Impact: The Path to Developing SenosensitizersSemantic proximity Read

Exosomes are key regulators of non-cell autonomous communication in senescenceSemantic proximity Read

Multiomics mapping and characterization of cellular senescence in aging human skeletal muscle uncovers a novel senotherapeutic for sarcopeniaSemantic proximity Read

Muscle stem cells in Duchenne muscular dystrophy exhibit molecular impairments and altered cell fate trajectories impacting regenerative capacitySemantic proximity Read

Senescence atlas reveals an aged-like inflamed niche that blunts muscle regenerationSemantic proximity Read

Single-cell-based evidence for GLS1 inhibitor as a bona fide senolytic agent in vivoSemantic proximity Read

Muscle stem cells in Duchenne muscular dystrophy exhibit molecular impairments and altered cell fate trajectories impacting regenerative capacitySemantic proximity Read

Senescent myoblasts exhibit an altered exometabolome that is linked to senescence-associated secretory phenotype signaling.Semantic proximity Read

Multiomics and cellular senescence profiling of aging human skeletal muscle uncovers Maraviroc as a senotherapeutic approach for sarcopeniaSemantic proximity Read