Article

Multiomics mapping and characterization of cellular senescence in aging human skeletal muscle uncovers a novel senotherapeutic for sarcopenia

2024-12-19

Abstract excerpt

<title>Abstract</title> <p>Cellular senescence is recognized as a hallmark of organismal aging but how it drives aging particularly in human tissues is not fully understood, partly due to the complex heterogeneous nature of senescence. Here in this study, we leverage single-nucleus multiomics to profile senescence in mononucleated cells of human skeletal muscle and provide the first senescence atlas. We demonstra...

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Literature Corpus work: 25ce0d34-dbd6-56b0-b298-7d20e85e00f2
DOI: 10.21203/rs.3.rs-5399514/v1

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