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Clearance of defective muscle stem cells by senolytics restores myogenesis in myotonic dystrophy type 1

19 Jul 2023

Abstract excerpt

Muscle stem cells, the engine of muscle repair, are affected in myotonic dystrophy type 1 (DM1); however, the underlying molecular mechanism and the impact on the disease severity are still elusive. Here, we show using patients' samples that muscle stem cells/myoblasts exhibit signs of cellular senescence in vitro and in situ. Single cell RNAseq uncovers a subset of senescent myoblasts expressing high levels of...

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PMID: 37468473
DOI: 10.1038/s41467-023-39663-3

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