Article

Muscle stem cells in Duchenne muscular dystrophy exhibit molecular impairments and altered cell fate trajectories impacting regenerative capacity

2024-07-24

Abstract excerpt

Satellite cells are muscle-resident stem cells that maintain and repair muscle. Increasing evidence supports the contributing role of satellite cells in Duchenne muscular dystrophy (DMD), a lethal degenerative muscle disease caused by loss of dystrophin. However, whether or not satellite cells exhibit dysfunction due to loss of dystrophin remains unresolved. Here, we used single cell RNA-sequencing (scRNA-seq) to...

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Literature Corpus work: 352f5d64-9236-5bd7-a2cb-30a75c537da1
DOI: 10.1101/2024.07.24.604963

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