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Article

Senolytic elimination of senescent macrophages restores muscle stem cell function in severely dystrophic muscle

8 Sept 2022

Abstract excerpt

The aging of the immune system, or immunosenescence, was recently verified to have a causal role in driving the aging of solid organs, while the senolytic elimination of senescent immune cells was found to effectively delay systemic aging. Our recent study also showed that immune cells in severely dystrophic muscles develop senescence-like phenotypes, including the increased expression of senescence-associated...

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PMID: 36084954
DOI: 10.18632/aging.204275

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