Clonal evolution and clinical implications of genetic abnormalities in blastic transformation of chronic myeloid leukaemia.

doi:10.1038/s41467-021-23097-w

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Article

Clonal evolution and clinical implications of genetic abnormalities in blastic transformation of chronic myeloid leukaemia.

Nature communications - 14 May 2021

Ochi Yotaro, Yoshida Kenichi, Huang Ying-Jung, Kuo Ming-Chung, Nannya Yasuhito, Sasaki Ko, Mitani Kinuko, Hosoya Noriko, Hiramoto Nobuhiro, Ishikawa Takayuki, Branford Susan, Shanmuganathan Naranie, Ohyashiki Kazuma, Takahashi Naoto, Takaku Tomoiku, Tsuchiya Shun, Kanemura Nobuhiro, Nakamura Nobuhiko, Ueda Yasunori, Yoshihara Satoshi, Bera Rabindranath, Shiozawa Yusuke, Zhao Lanying, Takeda June, Watatani Yosaku, Okuda Rurika, Makishima Hideki, Shiraishi Yuichi, Chiba Kenichi, Tanaka Hiroko, Sanada Masashi, Takaori-Kondo Akifumi, Miyano Satoru, Ogawa Seishi, Shih Lee-Yung

Abstract excerpt

Blast crisis (BC) predicts dismal outcomes in patients with chronic myeloid leukaemia (CML). Although additional genetic alterations play a central role in BC, the landscape and prognostic impact of these alterations remain elusive. Here, we comprehensively investigate genetic abnormalities in 136 BC and 148 chronic phase (CP) samples obtained from 216 CML patients using exome and targeted sequencing. One or more...

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Identifiers

PMID: 33990592
DOI: 10.1038/s41467-021-23097-w
PMCID: PMC8121838

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