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MPN Transformation Is Characterized By Heterogeneous Shifts In Lineage Character Resulting In Both HSC-Like And More Differentiated Lineage Signatures

2025-09-12

Abstract excerpt

<title>Abstract</title> <p>Philadelphia chromosome-negative myeloproliferative neoplasms (MPNs) have a propensity to transform to an accelerated or blast phase (MPN-AP/BP). The resulting disease has clinically similar manifestations to Acute Myeloid Leukemia (AML) but worse clinical outcomes. Here we present the first comprehensive description of the transcriptomic characteristics of MPN-AP/BP. Our analysis incor...

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Literature Corpus work: 2319342b-dabd-5218-a378-d0f80381915e
DOI: 10.21203/rs.3.rs-7539321/v1

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