Article

An in silico framework for evaluating PRS-guided prognostic enrichment in clinical trial design

2026-03-24

Abstract excerpt

<h4>Background</h4> Clinical trials are essential for therapeutic development but increasingly face challenges due to imprecise inclusion criteria, leading to low event rates and the need for large sample sizes. This inefficiency makes modern trials costly and time-consuming. Despite the availability of extensive clinical, genomic, and biological data, current trial enrollment strategies do not fully leverage thi...

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Literature Corpus work: 75c11bd7-7f07-58af-9864-24aad1f8aa6e
DOI: 10.64898/2026.03.21.26348974

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