Article
The benefits of using genetic information to design prevention trials.
American journal of human genetics - 4 Apr 2013
Hu Youna, Li Li, Ehm Margaret G, Bing Nan, Song Kijoung, Nelson Matthew R, Talmud Philippa J, Hingorani Aroon D, Kumari Meena, Kivimäki Mika, Xu Chun-Fang, Waterworth Dawn M, Whittaker John C, Abecasis Gonçalo R, Spino Cathie, Kang Hyun Min
Abstract excerpt
Clinical trials for preventative therapies are complex and costly endeavors focused on individuals likely to develop disease in a short time frame, randomizing them to treatment groups, and following them over time. In such trials, statistical power is governed by the rate of disease events in each group and cost is determined by randomization, treatment, and follow-up. Strategies that increase the rate of...
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