Article
The GenoVA study: Equitable implementation of a pragmatic randomized trial of polygenic-risk scoring in primary care.
American journal of human genetics - 2 Nov 2023
Vassy Jason L, Brunette Charles A, Lebo Matthew S, MacIsaac Katharine, Yi Thomas, Danowski Morgan E, Alexander Nicholas V J, Cardellino Mark P, Christensen Kurt D, Gala Manish, Green Robert C, Harris Elizabeth, Jones Natalie E, Kerman Benjamin J, Kraft Peter, Kulkarni Preetika, Lewis Anna C F, Lubitz Steven A, Natarajan Pradeep, Antwi Ashley A
Abstract excerpt
Polygenic risk scores (PRSs) hold promise for disease risk assessment and prevention. The Genomic Medicine at Veterans Affairs (GenoVA) Study is addressing three main challenges to the clinical implementation of PRSs in preventive care: defining and determining their clinical utility, implementing them in time-constrained primary care settings, and countering their potential to exacerbate healthcare disparities....
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