Article

Integrating genetic data in target trial emulations improves their design and informs the value of polygenic scores for prognostic and predictive enrichment

2024-11-05

Abstract excerpt

Randomized controlled trials (RCTs) are the gold standard for evaluating the efficacy and safety of medical interventions but ethical, practical, and financial limitations often necessitate decisions based on observational data. The increasing volume of such data has prompted regulatory bodies to rely more on real-world evidence, primarily obtained through trial emulations. This study explores how genetic data can...

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Literature Corpus work: ffdaf5b2-e1d5-5673-9f91-5d4041ccb0ed
DOI: 10.1101/2024.11.05.24316763

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