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Genetic, epigenetic and pharmacological influences modulating tissue specific regulation of the cannabinoid receptor-1 gene (CB <sub>1</sub> ); implications for cannabinoid pharmacogenetics

2019-02-08

Abstract excerpt

Cannabinoid receptor-1 (CB 1 ) represents a potential drug target against conditions that include obesity and substance abuse. However, drug trials targeting CB 1 (encoded by the CNR1 gene) have been compromised by differences in patient response. Towards addressing the hypothesis that genetic and epigenetic changes within the regulatory regions controlling CNR1 expression contribute to these differences, we iso...

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Literature Corpus work
75b95ad2-6443-580b-8a37-51e4de49c2ee
DOI
10.1101/544585
Open publication

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