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Article

Preclinical and Clinical Evidence for a Distinct Regulation of Mu Opioid and Type 1 Cannabinoid Receptor Genes Expression in Obesity

14 Jun 2019

Abstract excerpt

Among endogenous signaling networks involved in both rewarding and homeostatic mechanisms of obesity, a relevant role is played by the endocannabinoid (ECS) and the opioid (EOS) systems. We here studied the transcriptional regulation of ECS and EOS genes in the hypothalamus of Diet-induced obesity (DIO) rats, a preclinical model of obesity, as well as in humans with obesity and healthy controls. A significant and...

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PMID: 31258545
DOI: 10.3389/fgene.2019.00523

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