Article
Genes differentially expressed in CB1 knockout mice: involvement in the depressive-like phenotype.
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology - 1 Jan 2011
Aso Ester, Ozaita Andrés, Serra Miquel-Àngel, Maldonado Rafael
Abstract excerpt
Recent hypotheses to explain the neurobiology of depression underline the role played by stress in mood disorders. The endocannabinoid system is one of the major physiological substrates involved in emotional responses and stress. Thus, mice lacking CB(1) receptor exhibit a depressive-like phenotype and an increased vulnerability to deleterious effects of stress. In order to identify possible molecular pathways...
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