Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Rad51 presynaptic filament stabilization function of the mouse Swi5–Sfr1 heterodimeric complex

9 Apr 2012

Abstract excerpt

Homologous recombination (HR) represents a major error-free pathway to eliminate pre-carcinogenic chromosomal lesions. The DNA strand invasion reaction in HR is mediated by a helical filament of the Rad51 recombinase assembled on single-stranded DNA that is derived from the nucleolytic processing of the primary lesion. Recent studies have found that the human and mouse Swi5 and Sfr1 proteins form a complex that...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CRISPR and Genetic Engineering
Share to DNA Repair Mechanisms
Share to PARP inhibition in cancer therapy

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 22492707
DOI: 10.1093/nar/gks305

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Rad51 presynaptic filament stabilization function of the mouse Swi5–Sfr1 heterodimeric complexPMID 22492707Read ↗

The human Shu complex promotes RAD51 activity by modulating RPA dynamics on ssDNASemantic proximity Read ↗

Sgs1 Binding to Rad51 Stimulates Homology-Directed DNA Repair in Saccharomyces cerevisiae.Semantic proximity Read ↗

Human RAD51 paralogue SWSAP1 fosters RAD51 filament by regulating the anti-recombinase FIGNL1 AAA+ ATPaseSemantic proximity Read ↗

Novel insights into RAD51 activity and regulation during homologous recombination and DNA replicationSemantic proximity Read ↗

Remodeling and spacing factor 1 (RSF1) deposits centromere proteins at DNA double-strand breaks to promote non-homologous end-joiningSemantic proximity Read ↗

Phosphoregulation of DNA repair via the Rad51 auxiliary factor Swi5-Sfr1.Semantic proximity Read ↗

Distinct pathways of homologous recombination controlled by the SWS1-SWSAP1-SPIDR complexSemantic proximity Read ↗

Human RAD51 paralogue, SWSAP1, fosters RAD51 filament by regulating the anti-recombinase, FIGNL1 AAA+ ATPaseSemantic proximity Read ↗

Distinct pathways of homologous recombination controlled by the SWS1-SWSAP1-SPIDR complex.Semantic proximity Read ↗

Human RAD51 rapidly forms intrinsically dynamic nucleoprotein filaments modulated by nucleotide binding state.Semantic proximity Read ↗

Synergistic action of the Saccharomyces cerevisiae homologous recombination factors Rad54 and Rad51 in chromatin remodeling.Semantic proximity Read ↗

Distinct roles for the RSC and Swi/Snf ATP-dependent chromatin remodelers in DNA double-strand break repair.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.