Article

Distinct pathways of homologous recombination controlled by the SWS1-SWSAP1-SPIDR complex

2020-05-15

Abstract excerpt

Homology-directed repair (HDR), a critical DNA repair pathway in mammalian cells, is complex, leading to multiple outcomes with different impacts on genomic integrity. However, the factors that control these different outcomes are often not well understood. Here we show that SWS1-SWSAP1-SPIDR controls distinct types of HDR. Despite their requirement for stable assembly of RAD51 recombinase at DNA damage sites, the...

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Literature Corpus work: 3aede868-de89-58fc-a98c-814e81a90bbc
DOI: 10.1101/2020.05.15.098848

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