Article
Distinct pathways of homologous recombination controlled by the SWS1-SWSAP1-SPIDR complex.
Nature communications - 12 Jul 2021
Prakash Rohit, Sandoval Thomas, Morati Florian, Zagelbaum Jennifer A, Lim Pei-Xin, White Travis, Taylor Brett, Wang Raymond, Desclos Emilie C B, Sullivan Meghan R, Rein Hayley L, Bernstein Kara A, Krawczyk Przemek M, Gautier Jean, Modesti Mauro, Vanoli Fabio, Jasin Maria
Abstract excerpt
Homology-directed repair (HDR), a critical DNA repair pathway in mammalian cells, is complex, leading to multiple outcomes with different impacts on genomic integrity. However, the factors that control these different outcomes are often not well understood. Here we show that SWS1-SWSAP1-SPIDR controls distinct types of HDR. Despite their requirement for stable assembly of RAD51 recombinase at DNA damage sites,...
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