Characterization of hyperoxia-induced senescent lung macrophages in neonatal mice

Abstract excerpt

Bronchopulmonary dysplasia (BPD), a chronic lung disease in premature infants, results from mechanical ventilation and hyperoxia amongst other factors. We and others have shown that neonatal hyperoxia, known to lead to a BPD-like phenotype in rodent models, causes lung cellular senescence. In our 3-day hyperoxia model, the majority of senescent cells were lung macrophages, and these peaked at postnatal day (pnd) 7...

Topics

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• Bronchopulmonary Dysplasia
• Congenital Diaphragmatic Hernia Studies
• Genotype
• Hyperoxia
• Lung
• Mice
• Neonatal Respiratory Health Research
• Sequence Analysis, RNA

Identifiers and source

Literature Corpus work

7526ceeb-f084-58b2-8466-77f822f70903

DOI

10.1101/2025.05.09.652066