Article
Diverse homeostatic and immunomodulatory roles of immune cells in the developing mouse lung at single cell resolution.
eLife - 2 Jun 2020
Domingo-Gonzalez Racquel, Zanini Fabio, Che Xibing, Liu Min, Jones Robert C, Swift Michael A, Quake Stephen R, Cornfield David N, Alvira Cristina M
Abstract excerpt
At birth, the lungs rapidly transition from a pathogen-free, hypoxic environment to a pathogen-rich, rhythmically distended air-liquid interface. Although many studies have focused on the adult lung, the perinatal lung remains unexplored. Here, we present an atlas of the murine lung immune compartment during early postnatal development. We show that the late embryonic lung is dominated by specialized...
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