Article

The Aging Microenvironment Shapes Alveolar Macrophage Identity in Aging

2019-07-28

Abstract excerpt

A dysfunctional response to inhaled pathogens and toxins drives a substantial portion of the susceptibility to acute and chronic lung disease in the elderly. We used transcriptomic profiling combined with genetic lineage tracing, heterochronic adoptive transfer, parabiosis and treatment with metformin to show that the lung microenvironment defines the phenotype of long-lived alveolar macrophages during aging. Whil...

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Literature Corpus work: f4e7e734-2407-5b38-9ad9-a41cade75939
DOI: 10.1101/717033

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