Article

Mechanism and cellular actions of the potent AMPK inhibitor BAY-3827

2025-03-03

Abstract excerpt

Inhibition of AMP-activated protein kinase (AMPK) is under increasing investigation for its therapeutic potential in many diseases, including certain cancers. However, existing AMPK- inhibitors available as tool compounds are largely limited to compound C/dorsomorphin and SBI-0206965, both of which suffer from poor selectivity and off-target effects. Here we describe the structure-based molecular insights and cell...

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Literature Corpus work: 0737cacf-f5c0-5bcf-a658-faa3865e3732
DOI: 10.1101/2025.02.28.640688

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