Article

Identification of an allele-specific transcription factor binding interaction that regulates <i>PLA2G2A</i> gene expression

2023-12-13

Abstract excerpt

The secreted phospholipase A 2 (sPLA 2 ) isoform, sPLA 2 -IIA, has been implicated in a variety of diseases and conditions, including bacteremia, cardiovascular disease, COVID-19, sepsis, adult respiratory distress syndrome, and certain cancers. Given its significant role in these conditions, understanding the regulatory mechanisms impacting its levels is crucial. Genome-wide association studies (GWAS) have ide...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 750c0bcf-bf0c-5735-8c9b-c9e06b6b032f
DOI: 10.1101/2023.12.12.571290

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Identification of an allele-specific transcription factor binding interaction that regulates <i>PLA2G2A</i> gene expressionDOI 10.1101/2023.12.12.571290Read

Functional analysis of two PLA2G2A variants associated with secretory phospholipase A2-IIA levels.Semantic proximity Read

Tagging-SNP haplotype analysis of the secretory PLA2IIa gene PLA2G2A shows strong association with serum levels of sPLA2IIa: results from the UDACS study.Semantic proximity Read

The association of PLA2G2A single nucleotide polymorphisms with type IIa secretory phospholipase A2 level but not its activity in patients with stable coronary heart disease.Semantic proximity Read

Secretory phospholipase A(2)-IIA and cardiovascular disease: a mendelian randomization study.Semantic proximity Read

Molecular and functional characterization of polymorphisms in the secreted phospholipase A2 group X gene: relevance to coronary artery disease.Semantic proximity Read

Tagging SNP haplotype analysis of the secretory PLA2-V gene, PLA2G5, shows strong association with LDL and oxLDL levels, suggesting functional distinction from sPLA2-IIA: results from the UDACS study.Semantic proximity Read

PLA2G10 Gene Variants, sPLA2 Activity, and Coronary Heart Disease Risk.Semantic proximity Read

Novel genetic approach to investigate the role of plasma secretory phospholipase A2 (sPLA2)-V isoenzyme in coronary heart disease: modified Mendelian randomization analysis using PLA2G5 expression levels.Semantic proximity Read

FAS rs2234767 and rs1800682 polymorphisms jointly contributed to risk of colorectal cancer by affecting SP1/STAT1 complex recruitment to chromatin.Semantic proximity Read

Functional promoter variant in zinc finger protein 202 predicts severe atherosclerosis and ischemic heart disease.Semantic proximity Read

DNA Methylation of Patatin-Like Phospholipase Domain-Containing Protein 6 Gene Contributes to the Risk of Intracranial Aneurysm in MalesSemantic proximity Read

Transcriptional regulation of the human FPR2/ALX gene: evidence of a heritable genetic variant that impairs promoter activity.Semantic proximity Read