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DNA Methylation of Patatin-Like Phospholipase Domain-Containing Protein 6 Gene Contributes to the Risk of Intracranial Aneurysm in Males

11 Jul 2022

Abstract excerpt

Objective : This study is aimed to investigate the contribution of patatin-like phospholipase domain-containing protein 6 ( PNPLA6 ) DNA methylation to the risk of intracranial aneurysm (IA) in the Han Chinese population. Methods : A total of 96 age- and sex-matched participants were recruited to evaluate PNPLA6 methylation via bisulfite pyrosequencing. The PNPLA6 mRNA expression in the plasma was determined...

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PMID: 35898327
DOI: 10.3389/fnagi.2022.885680

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