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Article

Transcriptional regulation of the human FPR2/ALX gene: evidence of a heritable genetic variant that impairs promoter activity.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Mar 2012

Simiele Felice, Recchiuti Antonio, Mattoscio Domenico, De Luca Antonella, Cianci Eleonora, Franchi Sara, Gatta Valentina, Parolari Alessandro, Werba Josè Pablo, Camera Marina, Favaloro Bartolo, Romano Mario

Abstract excerpt

Lipoxin (LX) A(4,) a main endogenous stop-signal of inflammation, activates the G-protein-coupled receptor FPR2/ALX, which triggers potent anti-inflammatory signaling in vivo. Thus, the regulation of FPR2/ALX expression may have pathophysiological and therapeutic relevance. Here, we mapped a nucleotide sequence with strong FPR2/ALX promoter activity. Chromatin immunoprecipitation revealed specificity protein 1...

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PMID: 22131270
DOI: 10.1096/fj.11-198069

Genes

FPR2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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