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Article

Functional analysis of two PLA2G2A variants associated with secretory phospholipase A2-IIA levels.

PloS one - 1 Jan 2012

Exeter Holly J, Folkersen Lasse, Palmen Jutta, Franco-Cereceda Anders, Cooper Jackie A, Kalea Anastasia Z, Hooft Ferdinand Van't, Eriksson Per, Humphries Steve E, Talmud Philippa J

Abstract excerpt

BACKGROUND: Secretory phospholipase A2 group IIA (sPLA2-IIA) has been identified as a biomarker of atherosclerosis in observational and animal studies. The protein is encoded by the PLA2G2A gene and the aim of this study was to test the functionality of two PLA2G2A non-coding SNPs, rs11573156 C>G and rs3767221 T>G where the rare alleles have been previously associated with higher and lower sPLA2-IIA levels...

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Identifiers

PMID: 22879865
DOI: 10.1371/journal.pone.0041139
PMCID: PMC3412631

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