Article

A major disease-related point mutation in spastin alters dramatically the dynamics and allostery of the motor

2024-10-18

Abstract excerpt

Spastin is a microtubule-severing AAA+ ATPase that is highly expressed in neu-ronal cells and plays a crucial role in axonal growth, branching, and regeneration. This machine oligomerizes into hexamers in the presence of ATP and the microtubule carboxy-terminal tails (CTTs). Conformational changes in spastin hexamers, pow-ered by ATP hydrolysis, apply forces on the microtubule, ultimately leading to the severing o...

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Literature Corpus work: 74f39c52-795b-5d55-9e25-249c260599ef
DOI: 10.1101/2024.10.17.618886

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