Article

Structural and functional role of residues undergoing hereditary spastic paraplegias-linked mutations: insights from a simulation of the spiral to ring transition in katanin

2024-11-29

Abstract excerpt

Several dozen mutations in the large human spastin enzyme assembly have been associated with mobility impairment in hereditary spastic paraplegias. Some of them impact the structural determinants of two functional conformations of the protein, spiral and ring. Here we investigate the possible effect of the mutations on the transition between the two conformations, which is essential for the enzymatic function. By...

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Literature Corpus work: 1f2dc221-22ab-5a10-b4a4-6df74885fb14
DOI: 10.1101/2024.11.27.625675

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Structural and functional role of residues undergoing hereditary spastic paraplegias-linked mutations: insights from a simulation of the spiral to ring transition in kataninDOI 10.1101/2024.11.27.625675Read

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