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Article

The Drosophila homologue of the hereditary spastic paraplegia protein, spastin, severs and disassembles microtubules.

Current biology : CB - 12 Apr 2005

Roll-Mecak Antonina, Vale Ronald D

Abstract excerpt

Hereditary spastic paraplegias (HSPs), a group of neurodegenerative disorders characterized by lower-extremity spasticity and weakness, are most commonly caused by mutations in the spastin gene, which encodes a AAA+ ATPase related to the microtubule-severing protein katanin. A Drosophila homolog of spastin (D-spastin) was identified recently, and D-spastin RNAi-treated or genetic null flies show neurological...

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Identifiers

PMID: 15823537
DOI: 10.1016/j.cub.2005.02.029

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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The Drosophila homologue of the hereditary spastic paraplegia protein, spastin, severs and disassembles microtubules.PMID 15823537Read ↗

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