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Article

Recognition of C-terminal amino acids in tubulin by pore loops in Spastin is important for microtubule severing.

The Journal of cell biology - 26 Mar 2007

White Susan Roehl, Evans Katia J, Lary Jeffrey, Cole James L, Lauring Brett

Abstract excerpt

Spastin, an AAA ATPase mutated in the neurodegenerative disease hereditary spastic paraplegia, severs microtubules. Many other AAA proteins form ring-shaped hexamers and contain pore loops, which project into the ring's central cavity and act as ratchets that pull on target proteins, leading, in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 17389232
DOI: 10.1083/jcb.200610072
PMCID: PMC2064084

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-17389232-2026-09-04.1. Manifest publication-graph-cohort-2026-09-04.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

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Recognition of C-terminal amino acids in tubulin by pore loops in Spastin is important for microtubule severing.PMID 17389232Read ↗

Human spastin functions as an ATPase-independent microtubule nucleator via ring-stack formationSemantic proximity Read ↗

Conserved aromatic and basic amino acid residues in the pore region of Caenorhabditis elegans spastin play critical roles in microtubule severing.Semantic proximity Read ↗

The AAA ATPase spastin links microtubule severing to membrane modelling.Semantic proximity Read ↗

A major disease-related point mutation in spastin alters dramatically the dynamics and allostery of the motorSemantic proximity Read ↗

Spastin and microtubules: Functions in health and diseaseSemantic proximity Read ↗

Linking axonal degeneration to microtubule remodeling by Spastin-mediated microtubule severing.Semantic proximity Read ↗

The Drosophila homologue of the hereditary spastic paraplegia protein, spastin, severs and disassembles microtubules.Semantic proximity Read ↗

Spastin oligomerizes into a hexamer and the mutant spastin (E442Q) redistribute the wild-type spastin into filamentous microtubule.Semantic proximity Read ↗

Spastin, the protein mutated in autosomal dominant hereditary spastic paraplegia, is involved in microtubule dynamics.Semantic proximity Read ↗

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A newly identified NES sequence present in spastin regulates its subcellular localization and microtubule severing activity.Semantic proximity Read ↗

Drosophila spastin regulates synaptic microtubule networks and is required for normal motor function.Semantic proximity Read ↗

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