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Article

Unraveling Isoform Complexity: The Roles of M1- and M87-Spastin in Spastic Paraplegia 4 (SPG4).

Movement disorders : official journal of the Movement Disorder Society - 1 Mar 2025

Ramakrishnan Skandha, Mohan Neha, Dong Zhangji, Liu Mei, Qiang Liang

Abstract excerpt

Spastic Paraplegia 4 (SPG4) is a debilitating neurodegenerative disorder characterized by progressive muscle weakness and spasticity in the lower limbs, often leading to gait impairment. Central to SPG4 pathology is the die-back degeneration of corticospinal tracts, primarily driven by mutations in the spastin protein encoded by the SPAST gene. SPAST gives rise to two major spastin isoforms, M1- and M87-spastin,...

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Source

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Identifiers

PMID: 39614608
DOI: 10.1002/mds.30072
PMCID: PMC11928279

Genes

SPAST

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

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Unraveling Isoform Complexity: The Roles of M1- and M87-Spastin in Spastic Paraplegia 4 (SPG4).PMID 39614608Read ↗

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