Drosophila spastin regulates synaptic microtubule networks and is required for normal motor function.

Abstract excerpt

The most common form of human autosomal dominant hereditary spastic paraplegia (AD-HSP) is caused by mutations in the SPG4 (spastin) gene, which encodes an AAA ATPase closely related in sequence to the microtubule-severing protein Katanin. Patients with AD-HSP exhibit degeneration of the distal regions of the longest axons in the spinal cord. Loss-of-function mutations in the Drosophila spastin gene produce...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Axons
• Share to Central Nervous System
• Share to Electrophysiology