Article

USP29 is a novel non-canonical Hypoxia Inducible Factor-α activator

2020-02-20

Abstract excerpt

Hypoxia Inducible Factor (HIF) is the master transcriptional regulator that orchestrates cellular adaptation to low oxygen. HIF is tightly regulated via the stability of its α-subunit, which is subjected to oxygen-dependent proline hydroxylation by Prolyl-Hydroxylase Domain containing proteins (PHDs/EGLNs), and ultimately targeted for proteasomal degradation through poly-ubiquitination by von-Hippel-Lindau protein...

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Literature Corpus work: 74f03874-6a4f-5bff-b123-72da483e9f67
DOI: 10.1101/2020.02.20.957688

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