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Article

USP9X destabilizes pVHL and promotes cell proliferation.

Oncotarget - 13 Sept 2016

Zhang Cong, Peng Zuohan, Zhu Minglu, Wang Penglong, Du Xiao, Li Xiang, Liu Yu, Jin Yan, McNutt Michael A, Yin Yuxin

Abstract excerpt

Numerous mutations of the Von Hippel-Lindau (VHL) gene have been reported to cause dysfunction of VHL protein (pVHL) and lead to processes related to tumor progression. pVHL acts as an E3 ligase and degrades downstream targets, such as hypoxia-inducible transcription factor (HIF) which is essential for tumor growth. Previous studies reported reduction of VHL protein, rather than mRNA in VHL-related tumor...

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Source

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Identifiers

PMID: 27517496
DOI: 10.18632/oncotarget.11139
PMCID: PMC5312400

Genes

VHL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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