Article

USP28 enables oncogenic transformation of respiratory cells and its inhibition potentiates molecular therapy targeting mutant EGFR, BRAF and PI3K

2021-09-06

Abstract excerpt

Oncogenic transformation of lung epithelial cells is a multi-step process, frequently starting with the inactivation of tumor suppressors and subsequent activating mutations in proto-oncogenes, such as members of the PI3K or MAPK family. Cells undergoing transformation have to adjust to changes, such as metabolic requirements. This is achieved, in part, by modulating the protein abundance of transcription factors,...

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Literature Corpus work: fc58ffa8-3a7b-58bd-ac43-a983dc6fc9c5
DOI: 10.1101/2021.09.06.459088

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