Article
A Functional Genomic Screen Identifies the Deubiquitinase USP11 as a Novel Transcriptional Regulator of ERα in Breast Cancer.
Cancer research - 15 Nov 2020
Dwane Lisa, O'Connor Aisling E, Das Sudipto, Moran Bruce, Mulrane Laoighse, Pinto-Fernandez Adan, Ward Elspeth, Blümel Anna M, Cavanagh Brenton L, Mooney Brian, Dirac Annette M, Jirström Karin, Kessler Benedikt M, Ní Chonghaile Tríona, Bernards René, Gallagher William M, O'Connor Darran P
Abstract excerpt
Approximately 70% of breast cancers express estrogen receptor α (ERα) and depend on this key transcriptional regulator for proliferation and differentiation. While patients with this disease can be treated with targeted antiendocrine agents, drug resistance remains a significant issue, with almost half of patients ultimately relapsing. Elucidating the mechanisms that control ERα function may further our...
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