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Article

Tumor suppressor SPOP ubiquitinates and degrades EglN2 to compromise growth of prostate cancer cells.

Cancer letters - 1 Apr 2017

Zhang Linli, Peng Shan, Dai Xiangpeng, Gan Wenjian, Nie Xin, Wei Wenyi, Hu Guoqing, Guo Jianping

Abstract excerpt

EglN prolyl hydroxylases, a family of oxygen-sensing enzymes, hydroxylate distinct proteins to modulate diverse physiopathological signals. Aberrant regulations of EglNs result in multiple human diseases, including cancer. Different from EglN1 which function largely depends on the role of hypoxia-induce factor alpha (HIFα) in tumors, the functional significance and the upstream regulatory mechanisms of EglN2,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 28089830
DOI: 10.1016/j.canlet.2017.01.003
PMCID: PMC5511705

Genes

SPOP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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Tumor suppressor SPOP ubiquitinates and degrades EglN2 to compromise growth of prostate cancer cells.PMID 28089830Read ↗

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