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Profiling immunoglobulin repertoires across multiple human tissues using RNA sequencing

19 Jun 2020

Abstract excerpt

Profiling immunoglobulin (Ig) receptor repertoires with specialized assays can be cost-ineffective and time-consuming. Here we report ImReP, a computational method for rapid and accurate profiling of the Ig repertoire, including the complementary-determining region 3 (CDR3), using regular RNA sequencing data such as those from 8,555 samples across 53 tissues types from 544 individuals in the Genotype-Tissue...

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PMID: 32561710
DOI: 10.1038/s41467-020-16857-7

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