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Trichostatin A effects on gene expression in the protozoan parasite Entamoeba histolytica

5 Jul 2007

Abstract excerpt

BACKGROUND: Histone modification regulates chromatin structure and influences gene expression associated with diverse biological functions including cellular differentiation, cancer, maintenance of genome architecture, and pathogen virulence. In Entamoeba, a deep-branching eukaryote, short chain fatty acids (SCFA) affect histone acetylation and parasite development. Additionally, a number of active histone...

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PMID: 17612405
DOI: 10.1186/1471-2164-8-216

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