Inhibition of histone deacetylases alters allelic chromatin conformation at the imprinted U2af1-rs1 locus in mouse embryonic stem cells.

doi:10.1074/jbc.M105775200

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Article

Inhibition of histone deacetylases alters allelic chromatin conformation at the imprinted U2af1-rs1 locus in mouse embryonic stem cells.

The Journal of biological chemistry - 5 Apr 2002

Gregory Richard I, O'Neill Laura P, Randall Tamzin E, Fournier Cecile, Khosla Sanjeev, Turner Bryan M, Feil Robert

Abstract excerpt

Most loci that are regulated by genomic imprinting have differentially methylated regions (DMRs). Previously, we showed that the DMRs of the mouse Snrpn and U2af1-rs1 genes have paternal allele-specific patterns of acetylation on histones H3 and H4. To investigate the maintenance of acetylation at these DMRs, we performed chromatin immunoprecipitation on trichostatin-A (TSA)-treated and control cells. In...

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PMID: 11821379
DOI: 10.1074/jbc.M105775200

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