Article

Computational and functional characterization of the PI(4,5)P <sub>2</sub> binding site of the TRPM3 ion channel

2022-06-07

Abstract excerpt

<h4>ABSTRACT</h4> Transient Receptor Potential Melastatin 3 (TRPM3) is a heat-activated ion channel expressed in peripheral sensory neurons and the central nervous system. TRPM3 activity depends on the membrane phospholipid phosphatidylinositol 4,5-bisphosphate [PI(4,5)P 2 ], but the molecular mechanism of activation by PI(4,5)P 2 is not known. As no experimental structure of TRPM3 is available, we built a homo...

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Literature Corpus work: 749a1f9e-6e58-582b-976f-7de7e2a6cabe
DOI: 10.1101/2022.06.05.494899

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