Article

A duo of redox-sensitive pore-loop cysteines controls the activity of the neural ion channel TRPM3

2024-02-13

Abstract excerpt

<title>Abstract</title> <p> Transient Receptor Potential Melastatin 3 (TRPM3) is a non-selective, Ca <sup>2+</sup> -permeable ion channel that plays a pivotal role in peripheral thermosensation and nociception. Moreover, gain-of-function variants in TRPM3 underlie a spectrum of neurodevelopmental and epileptic disorders in humans, indicating an important role of TRPM3 in the central nervous system. Oxidative s...

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Literature Corpus work: 4024968c-a58b-560a-89df-4b1b587808e2
DOI: 10.21203/rs.3.rs-3911792/v1

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