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Article

A Cataract-Causing Mutation in the TRPM3 Cation Channel Disrupts Calcium Dynamics in the Lens.

Cells - 30 Jan 2024

Zhou Yuefang, Bennett Thomas M, Ruzycki Philip A, Guo Zhaohua, Cao Yu-Qing, Shahidullah Mohammad, Delamere Nicholas A, Shiels Alan

Abstract excerpt

TRPM3 belongs to the melastatin sub-family of transient receptor potential (TRPM) cation channels and has been shown to function as a steroid-activated, heat-sensitive calcium ion (Ca2+) channel. A missense substitution (p.I65M) in the TRPM3 gene of humans (TRPM3) and mice (Trpm3) has been shown to underlie an inherited form of early-onset, progressive cataract. Here, we model the pathogenetic effects of this...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 38334649
DOI: 10.3390/cells13030257
PMCID: PMC10854584

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