Article
Heat- and PIP2-dependent TRPM4 activity underlies mutually exclusive human diseases.
Proceedings of the National Academy of Sciences of the United States of America - 14 Apr 2026
Tian Yuhua, Bae Soohyeon, Wu Xuesong, Rouen Kyle C, Hernández-Gonzalez Adriana, Han Yanxiao, Tekreeti Abdullah Al, Vu Simon, Chen Irene, Li Ellen, Vorobyov Igor, Yarov-Yarovoy Vladimir, Suh Byung-Chang, Hwang Samuel T, Zheng Jie
Abstract excerpt
Temperature-sensitive transient receptor potential melastatin subfamily 4 (TRPM4) ion channels convert intracellular calcium increases into membrane depolarization, thereby linking these two powerful cellular signaling pathways in diverse physiological processes. TRPM4 mutations cause severe human hereditary cardiovascular and skin diseases; mysteriously, while these mutations are gain-of-function in nature, they...
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