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Article

Molecular determinants of phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2) binding to transient receptor potential V1 (TRPV1) channels.

The Journal of biological chemistry - 23 Jan 2015

Poblete Horacio, Oyarzún Ingrid, Olivero Pablo, Comer Jeffrey, Zuñiga Matías, Sepulveda Romina V, Báez-Nieto David, González Leon Carlos, González-Nilo Fernando, Latorre Ramón

Abstract excerpt

Phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2) has been recognized as an important activator of certain transient receptor potential (TRP) channels. More specifically, TRPV1 is a pain receptor activated by a wide range of stimuli. However, whether or not PI(4,5)P2 is a TRPV1 agonist remains op...

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Identifiers

PMID: 25425643
DOI: 10.1074/jbc.M114.613620
PMCID: PMC4303662

Genes

TRPV1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25425643-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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Molecular determinants of phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2) binding to transient receptor potential V1 (TRPV1) channels.PMID 25425643Read ↗

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