Article
Transient receptor potential melastatin 1 (TRPM1) is an ion-conducting plasma membrane channel inhibited by zinc ions.
The Journal of biological chemistry - 8 Apr 2011
Lambert Sachar, Drews Anna, Rizun Oleksandr, Wagner Thomas F J, Lis Annette, Mannebach Stefanie, Plant Sandra, Portz Melanie, Meissner Marcel, Philipp Stephan E, Oberwinkler Johannes
Abstract excerpt
TRPM1 is the founding member of the melastatin subgroup of transient receptor potential (TRP) proteins, but it has not yet been firmly established that TRPM1 proteins form ion channels. Consequently, the biophysical and pharmacological properties of these proteins are largely unknown. Here we show that heterologous expression of TRPM1 proteins induces ionic conductances that can be activated by extracellular...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.