Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Voltage- and temperature-dependent activation of TRPV3 channels is potentiated by receptor-mediated PI(4,5)P2 hydrolysis.

The Journal of general physiology - 1 Mar 2011

Doerner Julia F, Hatt Hanns, Ramsey I Scott

Abstract excerpt

TRPV3 is a thermosensitive channel that is robustly expressed in skin keratinocytes and activated by innocuous thermal heating, membrane depolarization, and chemical agonists such as 2-aminoethyoxy diphenylborinate, carvacrol, and camphor. TRPV3 modulates sensory thermotransduction, hair growth, and susceptibility to dermatitis in rodents, but the molecular mechanisms responsible for controlling TRPV3 channel...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to GTP-Binding Protein alpha Subunits, Gq-G11
Share to Ion Channel Gating

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Keratinocytes

Share to Phosphatidylinositol 4,5-Diphosphate

Share to Phospholipase C beta

Share to Receptors, Muscarinic

Share to Second Messenger Systems

Share to TRPV Cation Channels

Source

Open in PubMed Open full text

Identifiers

PMID: 21321070
DOI: 10.1085/jgp.200910388
PMCID: PMC3047606

Genes

TRPV3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Voltage- and temperature-dependent activation of TRPV3 channels is potentiated by receptor-mediated PI(4,5)P2 hydrolysis.PMID 21321070Read ↗

TRPV3.Semantic proximity Read ↗

PI(4,5)P2 regulates the activation and desensitization of TRPM8 channels through the TRP domain.Semantic proximity Read ↗

Molecular determinants of phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2) binding to transient receptor potential V1 (TRPV1) channels.Semantic proximity Read ↗

Heat- and PIP2-dependent TRPM4 activity underlies mutually exclusive human diseases.Semantic proximity Read ↗

TRPV3: time to decipher a poorly understood family member!Semantic proximity Read ↗

A modular PIP2 binding site as a determinant of capsaicin receptor sensitivity.Semantic proximity Read ↗

TRPV3 Ion Channel: From Gene to PharmacologySemantic proximity Read ↗

Dual regulation of TRPV1 channels by phosphatidylinositol via functionally distinct binding sites.Semantic proximity Read ↗

TRPV1.Semantic proximity Read ↗

Activation of TRPV3 Regulates Inflammatory Actions of Human Epidermal KeratinocytesSemantic proximity Read ↗

TRPV3: a 'more than skinny' channel.Semantic proximity Read ↗

PI3-kinase promotes TRPV2 activity independently of channel translocation to the plasma membrane.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.