Article

An inducible germ cell ablation chicken model for high-grade germline chimeras

2023-06-14

Abstract excerpt

Chicken embryos are a powerful and widely used animal model in developmental biology studies. After the development of CRISPR technology, gene-edited chickens have been generated by transferring primordial germ cells (PGCs) after genetic modifications. However, the low inheritance caused by the competition between host germ cells and the transferred ones is the most common complication and largely reduces the prod...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 748a4519-6caf-5ddc-849e-ccebde5671bc
DOI: 10.1101/2023.06.14.544953

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

An inducible germ cell ablation chicken model for high-grade germline chimerasDOI 10.1101/2023.06.14.544953Read

Targeted mutagenesis in chicken using CRISPR/Cas9 system.Semantic proximity Read

Efficient TALEN-mediated gene targeting of chicken primordial germ cells.Semantic proximity Read

CRISPR/Cas9 gene editing in a chicken model: current approaches and applications.Semantic proximity Read

PGC-based cryobanking, regeneration through germline chimera mating, and CRISPR/Cas9-mediated TYRP1 modification in indigenous Chinese chickensSemantic proximity Read

DNA damage hypersensitivity in chicken primordial germ cells limits CRISPR-Cas9 editing and supports an shRNA-based screening approachSemantic proximity Read

Successful production of genome-edited rats by the rGONAD method.Semantic proximity Read

A non-inheritable maternal Cas9-based multiple-gene editing system in mice.Semantic proximity Read

Testes of <i>DAZL</i> null sheep lack spermatogonia and maintain normal somatic cellsSemantic proximity Read

A total synthetic approach to CRISPR/Cas9 genome editing and homology directed repairSemantic proximity Read

Efficient generation of zebrafish maternal-zygotic mutants through transplantation of ectopically induced and Cas9/gRNA targeted primordial germ cells.Semantic proximity Read

Primordial Germ Cell Transplantation for CRISPR/Cas9-based Leapfrogging in Xenopus.Semantic proximity Read

Use of chicken models for the analysis of human disease.Semantic proximity Read