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PGC-based cryobanking, regeneration through germline chimera mating, and CRISPR/Cas9-mediated TYRP1 modification in indigenous Chinese chickens

2024-01-16

Abstract excerpt

<title>Abstract</title> <p>Primordial germ cells (PGCs) are essential precursors for sperm and eggs. PGCs are highly reliable for conserving chicken germplasm and producing genetically modified chickens. Currently, efforts to conserve native chicken germplasm through PGCs and research on genetically modified chickens using CRISPR/Cas9 are limited. In this study, we successfully established 289 PGC lines from eigh...

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Literature Corpus work: acc0c716-0ade-5762-bc4d-9d83962ce354
DOI: 10.21203/rs.3.rs-3849770/v1

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