Article

Substitution spectrum and selection at G-quadruplexes in great ape telomere-to-telomere genomes

2025-08-27

Abstract excerpt

G-quadruplexes (G4s) are noncanonical DNA secondary structures formed by runs of guanines (stems) connected by other nucleotides (loops). These structures are enriched at regulatory regions such as promoters, CpG islands, untranslated regions (UTRs), enhancers, and replication origins, where they play key roles in transcription and replication. Although prior studies have demonstrated that G4s exhibit higher mutat...

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Literature Corpus work: 745f4b25-f7cd-5a61-b9c5-715bb37d91ea
DOI: 10.1101/2025.08.24.671323

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